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Dissecting Structure-Activity-Relationships of Crebinostat: Brain Penetrant HDAC Inhibitors for Neuroepigenetic Regulation

Targeting chromatin-mediated epigenetic regulation has emerged as a potential avenue for developing novel therapeutics for a wide range of central nervous system disorders, including cognitive disorders and depression. Histone deacetylase (HDAC) inhibitors have been pursued as cognitive enhancers th...

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Podrobná bibliografie
Vydáno v:Bioorg Med Chem Lett
Hlavní autoři: Ghosh, Balaram, Zhao, Wen-Ning, Reis, Surya A., Patnaik, Debasis, Fass, Daniel M., Tsai, Li-Huei, Mazitschek, Ralph, Haggarty, Stephen J.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2016
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4753070/
https://ncbi.nlm.nih.gov/pubmed/26804233
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2016.01.022
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