Modeling Cyclosporine A Inhibition of the Distribution of a P-Glycoprotein PET Ligand, (11)C-Verapamil, into the Maternal Brain and Fetal Liver of the Pregnant Nonhuman Primate: Impact of Tissue Blood Flow and Site of Inhibition

Through PET imaging, our laboratory has studied the dynamic biodistribution of (11)C-verapamil, a P-gp substrate, in the non-human primate Macaca nemestrina. To gain detailed insight into the kinetics of verapamil transport across the blood–brain barrier (BBB) and the blood–placental barrier (BPB),...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:J Nucl Med
Hlavní autoři: Ke, Alice Ban, Eyal, Sara, Chung, Francisco S., Link, Jeanne M., Mankoff, David A., Muzi, Mark, Unadkat, Jashvant D.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2013
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4734747/
https://ncbi.nlm.nih.gov/pubmed/23359659
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2967/jnumed.112.111732
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky