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Imaging of Cyclosporine Inhibition of P-Glycoprotein Activity Using (11)C-Verapamil in the Brain: Studies of Healthy Humans
The multiple-drug resistance (MDR) transporter P-glycoprotein (P-gp) is highly expressed at the human blood–brain barrier (BBB). P-gp actively effluxes a wide variety of drugs from the central nervous system, including anticancer drugs. We have previously demonstrated P-gp activity at the human BBB...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2754733/ https://ncbi.nlm.nih.gov/pubmed/19617341 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2967/jnumed.108.059162 |
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