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Modeling Cyclosporine A Inhibition of the Distribution of a P-Glycoprotein PET Ligand, (11)C-Verapamil, into the Maternal Brain and Fetal Liver of the Pregnant Nonhuman Primate: Impact of Tissue Blood Flow and Site of Inhibition

Through PET imaging, our laboratory has studied the dynamic biodistribution of (11)C-verapamil, a P-gp substrate, in the non-human primate Macaca nemestrina. To gain detailed insight into the kinetics of verapamil transport across the blood–brain barrier (BBB) and the blood–placental barrier (BPB),...

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Detalhes bibliográficos
Publicado no:J Nucl Med
Main Authors: Ke, Alice Ban, Eyal, Sara, Chung, Francisco S., Link, Jeanne M., Mankoff, David A., Muzi, Mark, Unadkat, Jashvant D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4734747/
https://ncbi.nlm.nih.gov/pubmed/23359659
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2967/jnumed.112.111732
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