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Modeling Cyclosporine A Inhibition of the Distribution of a P-Glycoprotein PET Ligand, (11)C-Verapamil, into the Maternal Brain and Fetal Liver of the Pregnant Nonhuman Primate: Impact of Tissue Blood Flow and Site of Inhibition
Through PET imaging, our laboratory has studied the dynamic biodistribution of (11)C-verapamil, a P-gp substrate, in the non-human primate Macaca nemestrina. To gain detailed insight into the kinetics of verapamil transport across the blood–brain barrier (BBB) and the blood–placental barrier (BPB),...
Shranjeno v:
| izdano v: | J Nucl Med |
|---|---|
| Main Authors: | , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2013
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4734747/ https://ncbi.nlm.nih.gov/pubmed/23359659 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2967/jnumed.112.111732 |
| Oznake: |
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