Simultaneous PET Imaging of P-Glycoprotein Inhibition in Multiple Tissues in the Pregnant Non-Human Primate

Studies in rodents indicate that disruption of P-glycoprotein (P-gp) function increases drug distribution into tissues such as the brain and the developing fetus. To simultaneously and serially evaluate the impact of P-gp activity and inhibition on the tissue distribution of drugs in a more represen...

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Detalhes bibliográficos
Main Authors: Eyal, Sara, Chung, Francisco S., Muzi, Mark, Link, Jeanne M., Mankoff, David A., Kaddoumi, Amal, O’Sullivan, Finbarr, Hebert, Mary F., Unadkat, Jashvant D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2703489/
https://ncbi.nlm.nih.gov/pubmed/19403878
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2967/jnumed.108.059360
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