Regional P-glycoprotein Activity and Inhibition at the Human Blood-Brain Barrier as Imaged by Positron Emission Tomography

We evaluated the contribution of P-glycoprotein (P-gp) at the human blood-brain barrier (BBB) to regional brain drug distribution using positron emission tomography (PET). Eleven healthy volunteers underwent PET imaging with [(11)C]-verapamil before and during cyclosporine A infusion. Regional P-gp...

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Detalhes bibliográficos
Main Authors: Eyal, Sara, Ke, Ban, Muzi, Mark, Link, Jeanne M., Mankoff, David A., Collier, Ann C., Unadkat, Jashvant D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2939015/
https://ncbi.nlm.nih.gov/pubmed/20336065
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/clpt.2010.11
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