Activity of P-glycoprotein, a β-amyloid Transporter at the Blood-Brain Barrier, is Compromised in Patients with Mild Alzheimer’s Disease

Animal and histopathological studies of human brain support a role for P-glycoprotein (P-gp) in clearance of cerebral β-amyloid (Aβ) across the blood brain barrier (BBB). We tested the hypothesis that BBB P-gp activity is diminished in Alzheimer’s disease (AD) by accounting for AD-related reduction...

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發表在:J Nucl Med
Main Authors: Deo, Anand K., Borson, Soo, Link, Jeanne M., Domino, Karen, Eary, Janet F., Ke, Ban, Richards, Todd L., Mankoff, David A., Minoshima, Satoshi, O’Sullivan, Finbarr, Eyal, Sara, Hsiao, Peng, Maravilla, Ken, Unadkat, Jashvant D.
格式: Artigo
語言:Inglês
出版: 2014
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4691246/
https://ncbi.nlm.nih.gov/pubmed/24842892
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2967/jnumed.113.130161
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