Activity of P-glycoprotein, a β-amyloid Transporter at the Blood-Brain Barrier, is Compromised in Patients with Mild Alzheimer’s Disease

Animal and histopathological studies of human brain support a role for P-glycoprotein (P-gp) in clearance of cerebral β-amyloid (Aβ) across the blood brain barrier (BBB). We tested the hypothesis that BBB P-gp activity is diminished in Alzheimer’s disease (AD) by accounting for AD-related reduction...

Полное описание

Сохранить в:
Библиографические подробности
Опубликовано в: :J Nucl Med
Главные авторы: Deo, Anand K., Borson, Soo, Link, Jeanne M., Domino, Karen, Eary, Janet F., Ke, Ban, Richards, Todd L., Mankoff, David A., Minoshima, Satoshi, O’Sullivan, Finbarr, Eyal, Sara, Hsiao, Peng, Maravilla, Ken, Unadkat, Jashvant D.
Формат: Artigo
Язык:Inglês
Опубликовано: 2014
Предметы:
Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4691246/
https://ncbi.nlm.nih.gov/pubmed/24842892
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2967/jnumed.113.130161
Метки: Добавить метку
Нет меток, Требуется 1-ая метка записи!

Схожие документы