Imaging of Cyclosporine Inhibition of P-Glycoprotein Activity Using (11)C-Verapamil in the Brain: Studies of Healthy Humans

The multiple-drug resistance (MDR) transporter P-glycoprotein (P-gp) is highly expressed at the human blood–brain barrier (BBB). P-gp actively effluxes a wide variety of drugs from the central nervous system, including anticancer drugs. We have previously demonstrated P-gp activity at the human BBB...

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Hlavní autoři: Muzi, Mark, Mankoff, David A., Link, Jeanne M., Shoner, Steve, Collier, Ann C., Sasongko, Lucy, Unadkat, Jashvant D.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2009
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2754733/
https://ncbi.nlm.nih.gov/pubmed/19617341
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2967/jnumed.108.059162
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