Immunogenicity of stabilized HIV-1 envelope trimers with reduced exposure of non-neutralizing epitopes

The envelope glycoprotein trimer mediates HIV-1 entry into cells. The trimer is flexible, fluctuating between closed and more open conformations and sometimes sampling the fully open, CD4-bound form. We hypothesized that conformational flexibility could hinder the induction of broadly neutralizing a...

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Publicado no:Cell
Main Authors: de Taeye, Steven W., Ozorowski, Gabriel, de la Peña, Alba Torrents, Guttman, Miklos, Julien, Jean-Philippe, van den Kerkhof, Tom L.G.M., Burger, Judith A., Pritchard, Laura K., Pugach, Pavel, Yasmeen, Anila, Crampton, Jordan, Hu, Joyce, Bontjer, Ilja, Torres, Jonathan L., Arendt, Heather, DeStefano, Joanne, Koff, Wayne C., Schuitemaker, Hanneke, Eggink, Dirk, Berkhout, Ben, Dean, Hansi, LaBranche, Celia, Crotty, Shane, Crispin, Max, Montefiori, David C., Klasse, P. J., Lee, Kelly K., Moore, John P., Wilson, Ian A., Ward, Andrew B., Sanders, Rogier W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4732737/
https://ncbi.nlm.nih.gov/pubmed/26687358
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2015.11.056
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