Immunogenicity of stabilized HIV-1 envelope trimers with reduced exposure of non-neutralizing epitopes

The envelope glycoprotein trimer mediates HIV-1 entry into cells. The trimer is flexible, fluctuating between closed and more open conformations and sometimes sampling the fully open, CD4-bound form. We hypothesized that conformational flexibility could hinder the induction of broadly neutralizing a...

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發表在:Cell
Main Authors: de Taeye, Steven W., Ozorowski, Gabriel, de la Peña, Alba Torrents, Guttman, Miklos, Julien, Jean-Philippe, van den Kerkhof, Tom L.G.M., Burger, Judith A., Pritchard, Laura K., Pugach, Pavel, Yasmeen, Anila, Crampton, Jordan, Hu, Joyce, Bontjer, Ilja, Torres, Jonathan L., Arendt, Heather, DeStefano, Joanne, Koff, Wayne C., Schuitemaker, Hanneke, Eggink, Dirk, Berkhout, Ben, Dean, Hansi, LaBranche, Celia, Crotty, Shane, Crispin, Max, Montefiori, David C., Klasse, P. J., Lee, Kelly K., Moore, John P., Wilson, Ian A., Ward, Andrew B., Sanders, Rogier W.
格式: Artigo
語言:Inglês
出版: 2015
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4732737/
https://ncbi.nlm.nih.gov/pubmed/26687358
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2015.11.056
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