AlkB homolog 2 (ABH2) mediated repair of ethenoadenine lesions in mammalian DNA

Endogenous formation of the mutagenic DNA adduct 1,N(6)-ethenoadenosine (εA) originates from lipid peroxidation. Elevated levels of εA in cancer-prone tissues suggest a role for this adduct in the development of some cancers. The base excision repair (BER) pathway has been considered the principal r...

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Published in:Cancer Res
Main Authors: Ringvoll, Jeanette, Moen, Marivi N., Nordstrand, Line M., Meira, Lisiane B., Pang, Bo, Bekkelund, Anders, Dedon, Peter C., Bjelland, Svein, Samson, Leona D., Falnes, Pål Ø., Klungland, Arne
Format: Artigo
Language:Inglês
Published: 2008
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4725713/
https://ncbi.nlm.nih.gov/pubmed/18519673
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-08-0796
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