Viral AlkB proteins repair RNA damage by oxidative demethylation

Bacterial and mammalian AlkB proteins are iron(II)- and 2-oxoglutarate-dependent dioxygenases that reverse methylation damage, such as 1-methyladenine and 3-methylcytosine, in RNA and DNA. An AlkB-domain is encoded by the genome of numerous single-stranded, plant-infecting RNA viruses, the majority...

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Detalhes bibliográficos
Main Authors: van den Born, Erwin, Omelchenko, Marina V., Bekkelund, Anders, Leihne, Vibeke, Koonin, Eugene V., Dolja, Valerian V., Falnes, Pål Ø.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2008
Assuntos:
Genome Integrity, Repair and Replication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2553587/
https://ncbi.nlm.nih.gov/pubmed/18718927
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkn519
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