Bioinformatics and functional analysis define four distinct groups of AlkB DNA-dioxygenases in bacteria

The iron(II)- and 2-oxoglutarate (2OG)-dependent dioxygenase AlkB from Escherichia coli (EcAlkB) repairs alkylation damage in DNA by direct reversal. EcAlkB substrates include methylated bases, such as 1-methyladenine (m(1)A) and 3-methylcytosine (m(3)C), as well as certain bulkier lesions, for exam...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: van den Born, Erwin, Bekkelund, Anders, Moen, Marivi N., Omelchenko, Marina V., Klungland, Arne, Falnes, Pål Ø.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2009
Schlagworte:
Genome Integrity, Repair and Replication
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2790896/
https://ncbi.nlm.nih.gov/pubmed/19786499
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkp774
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