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Bioinformatics and functional analysis define four distinct groups of AlkB DNA-dioxygenases in bacteria
The iron(II)- and 2-oxoglutarate (2OG)-dependent dioxygenase AlkB from Escherichia coli (EcAlkB) repairs alkylation damage in DNA by direct reversal. EcAlkB substrates include methylated bases, such as 1-methyladenine (m(1)A) and 3-methylcytosine (m(3)C), as well as certain bulkier lesions, for exam...
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| Autori principali: | , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Oxford University Press
2009
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2790896/ https://ncbi.nlm.nih.gov/pubmed/19786499 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkp774 |
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