Human AlkB Homolog 1 Is a Mitochondrial Protein That Demethylates 3-Methylcytosine in DNA and RNA

The Escherichia coli AlkB protein and human homologs hABH2 and hABH3 are 2-oxoglutarate (2OG)/Fe(II)-dependent DNA/RNA demethylases that repair 1-methyladenine and 3-methylcytosine residues. Surprisingly, hABH1, which displays the strongest homology to AlkB, failed to show repair activity in two ind...

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Detalhes bibliográficos
Main Authors: Westbye, Marianne Pedersen, Feyzi, Emadoldin, Aas, Per Arne, Vågbø, Cathrine Broberg, Talstad, Vivi Anita, Kavli, Bodil, Hagen, Lars, Sundheim, Ottar, Akbari, Mansour, Liabakk, Nina-Beate, Slupphaug, Geir, Otterlei, Marit, Krokan, Hans Einar
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2008
Assuntos:
DNA: Replication, Repair, Recombination, and Chromosome Dynamics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3259822/
https://ncbi.nlm.nih.gov/pubmed/18603530
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M803776200
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