Divergent β-hairpins determine double-strand versus single-strand substrate recognition of human AlkB-homologues 2 and 3

Human AlkB homologues ABH2 and ABH3 repair 1-methyladenine and 3-methylcytosine in DNA/RNA by oxidative demethylation. The enzymes have similar overall folds and active sites, but are functionally divergent. ABH2 efficiently demethylates both single- and double-stranded (ds) DNA, whereas ABH3 has a...

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Bibliografiske detaljer
Main Authors: Monsen, Vivi Talstad, Sundheim, Ottar, Aas, Per Arne, Westbye, Marianne P., Sousa, Mirta M. L., Slupphaug, Geir, Krokan, Hans E.
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2010
Fag:
Genome Integrity, Repair and Replication
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2965238/
https://ncbi.nlm.nih.gov/pubmed/20525795
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkq518
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