Human ABH3 structure and key residues for oxidative demethylation to reverse DNA/RNA damage

Methylating agents are ubiquitous in the environment, and central in cancer therapy. The 1-methyladenine and 3-methylcytosine lesions in DNA/RNA contribute to the cytotoxicity of such agents. These lesions are directly reversed by ABH3 (hABH3) in humans and AlkB in Escherichia coli. Here, we report...

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Main Authors: Sundheim, Ottar, Vågbø, Cathrine B, Bjørås, Magnar, Sousa, Mirta M L, Talstad, Vivi, Aas, Per A, Drabløs, Finn, Krokan, Hans E, Tainer, John A, Slupphaug, Geir
Format: Artigo
Sprog:Inglês
Udgivet: 2006
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1523172/
https://ncbi.nlm.nih.gov/pubmed/16858410
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601219
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