Human ABH3 structure and key residues for oxidative demethylation to reverse DNA/RNA damage

Methylating agents are ubiquitous in the environment, and central in cancer therapy. The 1-methyladenine and 3-methylcytosine lesions in DNA/RNA contribute to the cytotoxicity of such agents. These lesions are directly reversed by ABH3 (hABH3) in humans and AlkB in Escherichia coli. Here, we report...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Sundheim, Ottar, Vågbø, Cathrine B, Bjørås, Magnar, Sousa, Mirta M L, Talstad, Vivi, Aas, Per A, Drabløs, Finn, Krokan, Hans E, Tainer, John A, Slupphaug, Geir
Formato: Artigo
Idioma:Inglês
Publicado em: 2006
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1523172/
https://ncbi.nlm.nih.gov/pubmed/16858410
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601219
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados