Repair deficient mice reveal mABH2 as the primary oxidative demethylase for repairing 1meA and 3meC lesions in DNA

Two human homologs of the Escherichia coli AlkB protein, denoted hABH2 and hABH3, were recently shown to directly reverse 1-methyladenine (1meA) and 3-methylcytosine (3meC) damages in DNA. We demonstrate that mice lacking functional mABH2 or mABH3 genes, or both, are viable and without overt phenoty...

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Autori principali: Ringvoll, Jeanette, Nordstrand, Line M, Vågbø, Cathrine B, Talstad, Vivi, Reite, Karen, Aas, Per Arne, Lauritzen, Knut H, Liabakk, Nina Beate, Bjørk, Alexandra, Doughty, Richard William, Falnes, Pål Ø, Krokan, Hans E, Klungland, Arne
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2006
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1462979/
https://ncbi.nlm.nih.gov/pubmed/16642038
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601109
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