UNG-initiated base excision repair is the major repair route for 5-fluorouracil in DNA, but 5-fluorouracil cytotoxicity depends mainly on RNA incorporation

Cytotoxicity of 5-fluorouracil (FU) and 5-fluoro-2′-deoxyuridine (FdUrd) due to DNA fragmentation during DNA repair has been proposed as an alternative to effects from thymidylate synthase (TS) inhibition or RNA incorporation. The goal of the present study was to investigate the relative contributio...

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Main Authors: Pettersen, Henrik Sahlin, Visnes, Torkild, Vågbø, Cathrine Broberg, Svaasand, Eva. K., Doseth, Berit, Slupphaug, Geir, Kavli, Bodil, Krokan, Hans E.
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2011
Assuntos:
Genome Integrity, Repair and Replication
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3201877/
https://ncbi.nlm.nih.gov/pubmed/21745813
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkr563
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