Uracil-DNA Glycosylase in Base Excision Repair and Adaptive Immunity: SPECIES DIFFERENCES BETWEEN MAN AND MOUSE

Genomic uracil is a DNA lesion but also an essential key intermediate in adaptive immunity. In B cells, activation-induced cytidine deaminase deaminates cytosine to uracil (U:G mispairs) in Ig genes to initiate antibody maturation. Uracil-DNA glycosylases (UDGs) such as uracil N-glycosylase (UNG), s...

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Detalhes bibliográficos
Main Authors: Doseth, Berit, Visnes, Torkild, Wallenius, Anders, Ericsson, Ida, Sarno, Antonio, Pettersen, Henrik Sahlin, Flatberg, Arnar, Catterall, Tara, Slupphaug, Geir, Krokan, Hans E., Kavli, Bodil
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Enzymology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3089509/
https://ncbi.nlm.nih.gov/pubmed/21454529
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.230052
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