Uracil–DNA glycosylase UNG1 isoform variant supports class switch recombination and repairs nuclear genomic uracil

UNG is the major uracil-DNA glycosylase in mammalian cells and is involved in both error-free base excision repair of genomic uracil and mutagenic uracil-processing at the antibody genes. However, the regulation of UNG in these different processes is currently not well understood. The UNG gene encod...

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Библиографические подробности
Опубликовано в: :Nucleic Acids Res
Главные авторы: Sarno, Antonio, Lundbæk, Marie, Liabakk, Nina Beate, Aas, Per Arne, Mjelle, Robin, Hagen, Lars, Sousa, Mirta M L, Krokan, Hans E, Kavli, Bodil
Формат: Artigo
Язык:Inglês
Опубликовано: Oxford University Press 2019
Предметы:
Genome Integrity, Repair and Replication
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6511853/
https://ncbi.nlm.nih.gov/pubmed/30838409
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz145
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