RPA2 winged-helix domain facilitates UNG-mediated removal of uracil from ssDNA; implications for repair of mutagenic uracil at the replication fork

Uracil occurs at replication forks via misincorporation of deoxyuridine monophosphate (dUMP) or via deamination of existing cytosines, which occurs 2–3 orders of magnitude faster in ssDNA than in dsDNA and is 100% miscoding. Tethering of UNG2 to proliferating cell nuclear antigen (PCNA) allows rapid...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Kavli, Bodil, Iveland, Tobias S, Buchinger, Edith, Hagen, Lars, Liabakk, Nina B, Aas, Per A, Obermann, Tobias S, Aachmann, Finn L, Slupphaug, Geir
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2021
Assuntos:
Genome Integrity, Repair and Replication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8053108/
https://ncbi.nlm.nih.gov/pubmed/33784377
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkab195
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