載入...

B cells from hyper-IgM patients carrying UNG mutations lack ability to remove uracil from ssDNA and have elevated genomic uracil

The generation of high-affinity antibodies requires somatic hypermutation (SHM) and class switch recombination (CSR) at the immunoglobulin (Ig) locus. Both processes are triggered by activation-induced cytidine deaminase (AID) and require UNG-encoded uracil-DNA glycosylase. AID has been suggested to...

全面介紹

Na minha lista:
書目詳細資料
Main Authors: Kavli, Bodil, Andersen, Sonja, Otterlei, Marit, Liabakk, Nina B., Imai, Kohsuke, Fischer, Alain, Durandy, Anne, Krokan, Hans E., Slupphaug, Geir
格式: Artigo
語言:Inglês
出版: The Rockefeller University Press 2005
主題:
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2212036/
https://ncbi.nlm.nih.gov/pubmed/15967827
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20050042
標簽: 添加標簽
沒有標簽, 成為第一個標記此記錄!