B cells from hyper-IgM patients carrying UNG mutations lack ability to remove uracil from ssDNA and have elevated genomic uracil

The generation of high-affinity antibodies requires somatic hypermutation (SHM) and class switch recombination (CSR) at the immunoglobulin (Ig) locus. Both processes are triggered by activation-induced cytidine deaminase (AID) and require UNG-encoded uracil-DNA glycosylase. AID has been suggested to...

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Main Authors: Kavli, Bodil, Andersen, Sonja, Otterlei, Marit, Liabakk, Nina B., Imai, Kohsuke, Fischer, Alain, Durandy, Anne, Krokan, Hans E., Slupphaug, Geir
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2005
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2212036/
https://ncbi.nlm.nih.gov/pubmed/15967827
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20050042
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