UNG-initiated base excision repair is the major repair route for 5-fluorouracil in DNA, but 5-fluorouracil cytotoxicity depends mainly on RNA incorporation

Cytotoxicity of 5-fluorouracil (FU) and 5-fluoro-2′-deoxyuridine (FdUrd) due to DNA fragmentation during DNA repair has been proposed as an alternative to effects from thymidylate synthase (TS) inhibition or RNA incorporation. The goal of the present study was to investigate the relative contributio...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Autori principali: Pettersen, Henrik Sahlin, Visnes, Torkild, Vågbø, Cathrine Broberg, Svaasand, Eva. K., Doseth, Berit, Slupphaug, Geir, Kavli, Bodil, Krokan, Hans E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2011
Soggetti:
Genome Integrity, Repair and Replication
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3201877/
https://ncbi.nlm.nih.gov/pubmed/21745813
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkr563
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi