Human AlkB Homolog ABH8 Is a tRNA Methyltransferase Required for Wobble Uridine Modification and DNA Damage Survival

tRNA nucleosides are extensively modified to ensure their proper function in translation. However, many of the enzymes responsible for tRNA modifications in mammals await identification. Here, we show that human AlkB homolog 8 (ABH8) catalyzes tRNA methylation to generate 5-methylcarboxymethyl uridi...

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Bibliografische gegevens
Hoofdauteurs: Fu, Dragony, Brophy, Jennifer A. N., Chan, Clement T. Y., Atmore, Kyle A., Begley, Ulrike, Paules, Richard S., Dedon, Peter C., Begley, Thomas J., Samson, Leona D.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Microbiology (ASM) 2010
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2863699/
https://ncbi.nlm.nih.gov/pubmed/20308323
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01604-09
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