Crystal Structure and RNA Binding Properties of the RNA Recognition Motif (RRM) and AlkB Domains in Human AlkB Homolog 8 (ABH8), an Enzyme Catalyzing tRNA Hypermodification

Humans express nine paralogs of the bacterial DNA repair enzyme AlkB, an iron/2-oxoglutarate-dependent dioxygenase that reverses alkylation damage to nucleobases. The biochemical and physiological roles of these paralogs remain largely uncharacterized, hampering insight into the evolutionary expansi...

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Bibliografiske detaljer
Main Authors: Pastore, Chiara, Topalidou, Irini, Forouhar, Farhad, Yan, Amy C., Levy, Matthew, Hunt, John F.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2012
Fag:
Protein Structure and Folding
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3265892/
https://ncbi.nlm.nih.gov/pubmed/22065580
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.286187
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