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Crystal structures of DNA/RNA repair enzymes AlkB and ABH2 bound to dsDNA

Escherichia coli AlkB and its human homologues ABH2 and ABH3 repair DNA/RNA base lesions by using a direct oxidative dealkylation mechanism. ABH2 has the primary role of guarding mammalian genomes against 1-meA damage by repairing this lesion in double-stranded DNA (dsDNA), whereas AlkB and ABH3 pre...

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Detalhes bibliográficos
Main Authors: Yang, Cai-Guang, Yi, Chengqi, Duguid, Erica M., Sullivan, Christopher T., Jian, Xing, Rice, Phoebe A., He, Chuan
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2587245/
https://ncbi.nlm.nih.gov/pubmed/18432238
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature06889
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