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Human AlkB homologue 1 (ABH1) exhibits DNA lyase activity at abasic sites
Bacterial AlkB and three human AlkB homologues (ABH1, ABH2, and ABH3) are Fe(2+)/2-oxoglutarate-dependent oxygenases that directly repair alkylation-damaged DNA. Here, we show that ABH1 unexpectedly has a second activity, cleaving DNA at abasic (AP) sites such as those arising spontaneously from alk...
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| 主要な著者: | , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2009
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2818486/ https://ncbi.nlm.nih.gov/pubmed/19959401 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2009.10.011 |
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