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A Covalent Protein-DNA 5′-Product Adduct is Generated Following AP Lyase Activity of Human AlkB Homolog 1 (ALKBH1)
ALKBH1 is a mammalian AlkB homolog that possesses abasic site (AP) lyase activity. The AP lyase reaction is catalyzed by imine formation with an active site Lys, and a covalent intermediate can be trapped in the presence of NaBH(4). Surprisingly, ALKBH1 also forms a stable protein-DNA adduct in the...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4126167/ https://ncbi.nlm.nih.gov/pubmed/23577621 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20121908 |
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