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Biochemical characterization of AP lyase and m(6)A demethylase activities of human AlkB homolog 1 (ALKBH1)

Alkbh1 is one of nine mammalian homologs of Escherichia coli AlkB, a 2-oxoglutarate-dependent dioxygenase that catalyzes direct DNA repair by removing alkyl lesions from DNA. Six distinct enzymatic activities have been reported for Alkbh1, including hydroxylation of variously methylated DNA, mRNA, t...

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Bibliographic Details
Published in:Biochemistry
Main Authors: Müller, Tina A., Tobar, Michael A., Perian, Madison N., Hausinger, Robert P.
Format: Artigo
Language:Inglês
Published: 2017
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5444387/
https://ncbi.nlm.nih.gov/pubmed/28290676
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.7b00060
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