Llwytho...
Human AlkB homologue 1 (ABH1) exhibits DNA lyase activity at abasic sites
Bacterial AlkB and three human AlkB homologues (ABH1, ABH2, and ABH3) are Fe(2+)/2-oxoglutarate-dependent oxygenases that directly repair alkylation-damaged DNA. Here, we show that ABH1 unexpectedly has a second activity, cleaving DNA at abasic (AP) sites such as those arising spontaneously from alk...
Wedi'i Gadw mewn:
| Prif Awduron: | , , |
|---|---|
| Fformat: | Artigo |
| Iaith: | Inglês |
| Cyhoeddwyd: |
2009
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| Pynciau: | |
| Mynediad Ar-lein: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2818486/ https://ncbi.nlm.nih.gov/pubmed/19959401 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2009.10.011 |
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