MUC1 Vaccines, Comprised of Glycosylated or Non-Glycosylated Peptides or Tumor-Derived MUC1, Can Circumvent Immunoediting to Control Tumor Growth in MUC1 Transgenic Mice

It remains challenging to produce decisive vaccines against MUC1, a tumor-associated antigen widely expressed by pancreas, breast and other tumors. Employing clinically relevant mouse models, we ruled out such causes as irreversible T-cell tolerance, inadequate avidity, and failure of T-cells to rec...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Lakshminarayanan, Vani, Supekar, Nitin T., Wei, Jie, McCurry, Dustin B., Dueck, Amylou C., Kosiorek, Heidi E., Trivedi, Priyanka P., Bradley, Judy M., Madsen, Cathy S., Pathangey, Latha B., Hoelzinger, Dominique B., Wolfert, Margreet A., Boons, Geert-Jan, Cohen, Peter A., Gendler, Sandra J.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4720451/
https://ncbi.nlm.nih.gov/pubmed/26788922
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0145920
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