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Aberrant Glycosylation of Anchor-Optimized MUC1 Peptides Can Enhance Antigen Binding Affinity and Reverse Tolerance to Cytotoxic T Lymphocytes

Cancer vaccines have often failed to live up to their promise, although recent results with checkpoint inhibitors are reviving hopes that they will soon fulfill their promise. Although mutation-specific vaccines are under development, there is still high interest in an off-the-shelf vaccine to a ubi...

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Vydáno v:Biomolecules
Hlavní autoři: Pathangey, Latha B., Lakshminarayanan, Vani, Suman, Vera J., Pockaj, Barbara A., Mukherjee, Pinku, Gendler, Sandra J.
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI 2016
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5039417/
https://ncbi.nlm.nih.gov/pubmed/27367740
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/biom6030031
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