Immune recognition of tumor-associated mucin MUC1 is achieved by a fully synthetic aberrantly glycosylated MUC1 tripartite vaccine

The mucin MUC1 is typically aberrantly glycosylated by epithelial cancer cells manifested by truncated O-linked saccharides. The resultant glycopeptide epitopes can bind cell surface major histocompatibility complex (MHC) molecules and are susceptible to recognition by cytotoxic T lymphocytes (CTLs)...

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Hlavní autoři: Lakshminarayanan, Vani, Thompson, Pamela, Wolfert, Margreet A., Buskas, Therese, Bradley, Judy M., Pathangey, Latha B., Madsen, Cathy S., Cohen, Peter A., Gendler, Sandra J., Boons, Geert-Jan
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2012
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3252914/
https://ncbi.nlm.nih.gov/pubmed/22171012
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1115166109
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