Linear synthesis and immunological properties of a fully synthetic vaccine candidate containing a sialylated MUC1 glycopeptide()

A strategy for the linear synthesis of a sialylated glycolipopeptide cancer vaccine candidate has been developed using a strategically designed sialyl-Tn building block and microwave-assisted solid-phase peptide synthesis. The glycolipopeptide elicited potent humoral and cellular immune responses. T...

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Veröffentlicht in:Chem Commun (Camb)
Hauptverfasser: Thompson, Pamela, Lakshminarayanan, Vani, Supekar, Nitin T., Bradley, Judy M., Cohen, Peter A., Wolfert, Margreet A., Gendler, Sandra J., Boons, Geert-Jan
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4486256/
https://ncbi.nlm.nih.gov/pubmed/26022217
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c5cc02199e
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