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Sestrin2 is a leucine sensor for the mTORC1 pathway
Leucine is a proteogenic amino acid that also regulates many aspects of mammalian physiology, in large part by activating the mTOR complex 1 (mTORC1) protein kinase, a master growth controller. Amino acids signal to mTORC1 through the Rag guanine triphosphatases (GTPases). Several factors regulate t...
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| Publicado en: | Science |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2015
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4698017/ https://ncbi.nlm.nih.gov/pubmed/26449471 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aab2674 |
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