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CREB pathway links PGE2 signaling with macrophage polarization

Obesity is thought to promote insulin resistance in part via activation of the innate immune system. Increases in proinflammatory cytokine production by M1 macrophages inhibit insulin signaling in white adipose tissue. In contrast, M2 macrophages have been found to enhance insulin sensitivity in par...

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書誌詳細
出版年:Proc Natl Acad Sci U S A
主要な著者: Luan, Bing, Yoon, Young-Sil, Le Lay, John, Kaestner, Klaus H., Hedrick, Susan, Montminy, Marc
フォーマット: Artigo
言語:Inglês
出版事項: National Academy of Sciences 2015
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4697393/
https://ncbi.nlm.nih.gov/pubmed/26644581
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1519644112
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