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CREB pathway links PGE2 signaling with macrophage polarization

Obesity is thought to promote insulin resistance in part via activation of the innate immune system. Increases in proinflammatory cytokine production by M1 macrophages inhibit insulin signaling in white adipose tissue. In contrast, M2 macrophages have been found to enhance insulin sensitivity in par...

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Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Luan, Bing, Yoon, Young-Sil, Le Lay, John, Kaestner, Klaus H., Hedrick, Susan, Montminy, Marc
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2015
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4697393/
https://ncbi.nlm.nih.gov/pubmed/26644581
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1519644112
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