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Feedback Inhibition of CREB Signaling Promotes Beta Cell Dysfunction in Insulin Resistance
Although persistent elevations in circulating glucose concentrations promote compensatory increases in pancreatic islet mass, unremitting insulin resistance causes a deterioration in beta cell function that leads to the progression to diabetes. Here we show that mice with a knockout of the CREB coac...
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| Veröffentlicht in: | Cell Rep |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2015
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4872509/ https://ncbi.nlm.nih.gov/pubmed/25704817 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.01.046 |
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