Feedback Inhibition of CREB Signaling Promotes Beta Cell Dysfunction in Insulin Resistance

Although persistent elevations in circulating glucose concentrations promote compensatory increases in pancreatic islet mass, unremitting insulin resistance causes a deterioration in beta cell function that leads to the progression to diabetes. Here we show that mice with a knockout of the CREB coac...

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Detaylı Bibliyografya
Yayımlandı:Cell Rep
Asıl Yazarlar: Blanchet, Emilie, Van de Velde, Sam, Matsumura, Shigenobu, Hao, Ergeng, LeLay, John, Kaestner, Klaus, Montminy, Marc
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2015
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4872509/
https://ncbi.nlm.nih.gov/pubmed/25704817
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.01.046
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