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CREB pathway links PGE2 signaling with macrophage polarization

Obesity is thought to promote insulin resistance in part via activation of the innate immune system. Increases in proinflammatory cytokine production by M1 macrophages inhibit insulin signaling in white adipose tissue. In contrast, M2 macrophages have been found to enhance insulin sensitivity in par...

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Bibliografske podrobnosti
izdano v:Proc Natl Acad Sci U S A
Main Authors: Luan, Bing, Yoon, Young-Sil, Le Lay, John, Kaestner, Klaus H., Hedrick, Susan, Montminy, Marc
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2015
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4697393/
https://ncbi.nlm.nih.gov/pubmed/26644581
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1519644112
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