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CREB pathway links PGE2 signaling with macrophage polarization
Obesity is thought to promote insulin resistance in part via activation of the innate immune system. Increases in proinflammatory cytokine production by M1 macrophages inhibit insulin signaling in white adipose tissue. In contrast, M2 macrophages have been found to enhance insulin sensitivity in par...
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| 發表在: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
National Academy of Sciences
2015
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4697393/ https://ncbi.nlm.nih.gov/pubmed/26644581 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1519644112 |
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