CREB pathway links PGE2 signaling with macrophage polarization

Obesity is thought to promote insulin resistance in part via activation of the innate immune system. Increases in proinflammatory cytokine production by M1 macrophages inhibit insulin signaling in white adipose tissue. In contrast, M2 macrophages have been found to enhance insulin sensitivity in par...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Luan, Bing, Yoon, Young-Sil, Le Lay, John, Kaestner, Klaus H., Hedrick, Susan, Montminy, Marc
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2015
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4697393/
https://ncbi.nlm.nih.gov/pubmed/26644581
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1519644112
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