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Synthesis and evaluation of N-(methylthiophenyl)picolinamide derivatives as PET radioligands for metabotropic glutamate receptor subtype 4

In recent years, mGlu(4) has received great research attention because of the potential benefits of mGlu(4) activation in treating numerous brain disorders, such as Parkinson’s disease (PD). A specific mGlu(4) PET radioligand could be an important tool in understanding the role of mGlu(4) in both he...

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Bibliographic Details
Published in:Bioorg Med Chem Lett
Main Authors: Kil, Kun-Eek, Poutiainen, Pekka, Zhang, Zhaoda, Zhu, Aijun, Kuruppu, Darshini, Prabhakar, Shilpa, Choi, Ji-Kyung, Tannous, Bakhos A., Brownell, Anna-Liisa
Format: Artigo
Language:Inglês
Published: 2015
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4684791/
https://ncbi.nlm.nih.gov/pubmed/26602273
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2015.11.015
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