Precision Medicine in Multiple Sclerosis: Future of PET Imaging of Inflammation and Reactive Astrocytes

Por Poutiainen, Pekka, Jaronen, Merja, Quintana, Francisco J., Brownell, Anna-Liisa
Publicado no Front Mol Neurosci (2016)

Co-operative binding assay for the characterization of mGlu(4) allosteric modulators

Por Poutiainen, Pekka, Kil, Kun-Eek, Zhang, Zhaoda, Kuruppu, Darshini, Tannous, Bakhos, Brownell, Anna-Liisa
Publicado no Neuropharmacology (2015)

PET imaging studies show enhanced expression of mGluR5 and inflammatory response during progressive degeneration in ALS mouse model expressing SOD1-G93A gene

Por Brownell, Anna-Liisa, Kuruppu, Darshini, Kil, Kun-Eek, Jokivarsi, Kimmo, Poutiainen, Pekka, Zhu, Aijun, Maxwell, Michelle
Publicado no J Neuroinflammation (2015)

Radiosynthesis and Evaluation of an (18)F-Labeled Positron Emission Tomography (PET) Radioligand for Metabotropic Glutamate Receptor Subtype 4 (mGlu(4))

Por Kil, Kun-Eek, Poutiainen, Pekka, Zhang, Zhaoda, Zhu, Aijun, Choi, Ji-Kyung, Jokivarsi, Kimmo, Brownell, Anna-Liisa
Publicado no J Med Chem (2014)

Loss of Metabotropic Glutamate Receptor 5 Function on Peripheral Benzodiazepine Receptor in Mice Prenatally Exposed to LPS

Por Arsenault, Dany, Coulombe, Katherine, Zhu, Aijun, Gong, Chunyu, Kil, Kun-Eek, Choi, Ji-Kyung, Poutiainen, Pekka, Brownell, Anna-Liisa
Publicado no PLoS One (2015)

Re-exploring the N-phenylpicolinamide derivatives to develop mGlu(4) ligands with improved affinity and in vitro microsomal stability

Por Zhang, Zhaoda, Kil, Kun-Eek, Poutiainen, Pekka, Choi, Ji-Kyung, Kang, Hye-Jin, Huang, Xi-Ping, Roth, Bryan L, Brownell, Anna-Liisa
Publicado no Bioorg Med Chem Lett (2015)

Synthesis and evaluation of N-(methylthiophenyl)picolinamide derivatives as PET radioligands for metabotropic glutamate receptor subtype 4

Por Kil, Kun-Eek, Poutiainen, Pekka, Zhang, Zhaoda, Zhu, Aijun, Kuruppu, Darshini, Prabhakar, Shilpa, Choi, Ji-Kyung, Tannous, Bakhos A., Brownell, Anna-Liisa
Publicado no Bioorg Med Chem Lett (2015)

Functional modulation of G-protein coupled receptors during Parkinson disease-like neurodegeneration

Por Jenkins, Bruce, Zhu, Aijun, Poutiainen, Pekka, Choi, Ji-Kyung, Kil, Kun-Eek, Zhang, Zhaoda, Kuruppu, Darshini, Aytan, Nurgul, Dedeoglu, Alpaslan, Brownell, Anna-Liisa
Publicado no Neuropharmacology (2015)