Radiosynthesis and Evaluation of an (18)F-Labeled Positron Emission Tomography (PET) Radioligand for Metabotropic Glutamate Receptor Subtype 4 (mGlu(4))

[Image: see text] Four 4-phthalimide derivatives of N-(3-chlorophenyl)-2-picolinamide were synthesized as potential ligands for the PET imaging of mGlu(4) in the brain. Of these compounds, N-(3-chloro-4-(4-fluoro-1,3-dioxoisoindolin-2-yl)phenyl)-2-picolinamide (3, KALB001) exhibited improved binding...

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Bibliografiska uppgifter
I publikationen:J Med Chem
Huvudupphovsmän: Kil, Kun-Eek, Poutiainen, Pekka, Zhang, Zhaoda, Zhu, Aijun, Choi, Ji-Kyung, Jokivarsi, Kimmo, Brownell, Anna-Liisa
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Chemical Society 2014
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4230996/
https://ncbi.nlm.nih.gov/pubmed/25330258
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm501245b
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