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Radiosynthesis of N-(4-chloro-3-[(11)C]methoxyphenyl)-2-picolinamide ([(11)C]ML128) as a PET radiotracer for metabotropic glutamate receptor subtype 4 (mGlu(4))

N-(Chloro-3-methoxyphenyl)-2-picolinamide (3, ML128, VU0361737) is an mGlu(4) positive allosteric modulator (PAM), which is potent and centrally penetrating. 3 is also the first mGlu(4) PAM to show efficacy in a preclinical Parkinson disease model upon systemic dosing. As a noninvasive medical imagi...

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Detaylı Bibliyografya
Asıl Yazarlar: Kil, Kun-Eek, Zhang, Zhaoda, Jokivarsi, Kimmo, Gong, Chunyu, Choi, Ji-Kyung, Kura, Sreekanth, Brownell, Anna-Liisa
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2013
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3811911/
https://ncbi.nlm.nih.gov/pubmed/23978356
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2013.07.046
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