High throughput cross-interaction measures for human IgG1 antibodies correlate with clearance rates in mice

Although improvements in technology for the isolation of potential therapeutic antibodies have made the process increasingly predictable, the development of biologically active monoclonal antibodies (mAbs) into drugs can often be impeded by developability issues such as poor expression, solubility,...

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Bibliografski detalji
Izdano u:MAbs
Glavni autori: Kelly, Ryan L, Sun, Tingwan, Jain, Tushar, Caffry, Isabelle, Yu, Yao, Cao, Yuan, Lynaugh, Heather, Brown, Michael, Vásquez, Maximiliano, Wittrup, K Dane, Xu, Yingda
Format: Artigo
Jezik:Inglês
Izdano: Taylor & Francis 2015
Teme:
Report
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4622737/
https://ncbi.nlm.nih.gov/pubmed/26047159
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2015.1043503
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