High throughput cross-interaction measures for human IgG1 antibodies correlate with clearance rates in mice

Although improvements in technology for the isolation of potential therapeutic antibodies have made the process increasingly predictable, the development of biologically active monoclonal antibodies (mAbs) into drugs can often be impeded by developability issues such as poor expression, solubility,...

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Sparad:
Bibliografiska uppgifter
I publikationen:MAbs
Huvudupphovsmän: Kelly, Ryan L, Sun, Tingwan, Jain, Tushar, Caffry, Isabelle, Yu, Yao, Cao, Yuan, Lynaugh, Heather, Brown, Michael, Vásquez, Maximiliano, Wittrup, K Dane, Xu, Yingda
Materialtyp: Artigo
Språk:Inglês
Publicerad: Taylor & Francis 2015
Ämnen:
Report
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4622737/
https://ncbi.nlm.nih.gov/pubmed/26047159
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2015.1043503
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