High-throughput screening for developability during early-stage antibody discovery using self-interaction nanoparticle spectroscopy

The discovery of monoclonal antibodies (mAbs) that bind to a particular molecular target is now regarded a routine exercise. However, the successful development of mAbs that (1) express well, (2) elicit a desirable biological effect upon binding, and (3) remain soluble and display low viscosity at h...

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Bibliografiske detaljer
Main Authors: Liu, Yuqi, Caffry, Isabelle, Wu, Jiemin, Geng, Steven B, Jain, Tushar, Sun, Tingwan, Reid, Felicia, Cao, Yuan, Estep, Patricia, Yu, Yao, Vásquez, Maximiliano, Tessier, Peter M, Xu, Yingda
Format: Artigo
Sprog:Inglês
Udgivet: Landes Bioscience 2014
Fag:
Report
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3984336/
https://ncbi.nlm.nih.gov/pubmed/24492294
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/mabs.27431
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